Hospital Raja Perempuan Zainab II

Hospital Kota Bharu was established in the 1920s. In remembrance of the late Sultanah Kelantan, this tertiary care facility name was changed to Hospital Raja Perempuan Zainab II (HRPZII) and the ceremony was officiated by Kebawah Duli Yang Maha Mulia Al-Sultan Kelantan Tuanku Ismail Petra Ibni Almarhum Sultan Yahya Petra on 5 September 2005.  HRPZII is the main referral centre for the entire state of Kelantan and Northern District of  Terengganu. The undergraduate medical students from University Sains Malaysia (USM) and Post Graduate Distance Learning Program (PJJ) doctors use HRPZII for their practical training, as well as trainees preparing for examination conducted by Universiti Kebangsaan Malaysia (UKM), USM and professional bodies overseas. Basic and post basic training for paramedical personnel and are conducted as in-service training for all categories of staff. In addition, HRPZII was recently appointed as a Regional Hub for Telemedicine, Regional Referral Centre for Psychiatry service and Regional Clinical Research Centre (CRC).


  • Accident & emergency
  • Anesthesiology
  • Dermatology
  • Forensic
  • Medical
  • Nephrology
  • Obstetrics & Gynaecology (O&G)
  • Ophthalmology
  • Oral surgery
  • Orthopaedic
  • Otorhinolaryngology
  • Pathology
  • Pediatric
  • Psychiatry
  • Radiology
  • Rehabilitation
  • Surgical


Evolution of CRC Kelantan


  • CRC Hospital Kota Bharu created and operated as one of the quality activities at hospital level.


  • Renamed to CRC Kelantan and has expanded its scope of services to state level.
  • Operates as an independent unit and is listed among other units and departments at HRPZII.


  • CRM SC joins in as part of CRC Kelantan.
  • Officially selected as 1 out of 11 IQVIA (previously known as Quintiles) Prime Sites.


  • CRC Kelantan office relocated to hospital staff quarters.
  • Comprises of 2 treatment rooms/clinics and research room used to conduct Industry Sponsored Research (ISR) and Investigator Initiated Research (IIR).


  • Addition of CRC office space, SIV/monitoring room, Head of Unit room, staffroom,   record room and tutorial room.


  • Officially selected as PARAXEL Preferred Site.

Total  staff : 19
Specialist : 2
Medical officer : 2
Pharmacist : 1
Research officer : 1
Nurse : 2
Administrative officer : 1
Contract Officer : 1
CRM Study Coordinator : 7
Freelance Study Coordinator : 2




  • NMRR online registration
  • Protocol & proposal development
  • Literature search / review
  • Review of Research Protocol for IIR
  • Statistical consultation
  • Manuscript and abstract write up
  • Assist in submission of research papers
  • Assist in grant application


  • Good Clinical Practice (GCP)
  • Introduction to Clinical Research (ICR) Workshop
  • Statistical Analysis Workshop
  • Study Coordinator Workshop
  • Research Methodology Workshop
  • Scientific Writing Workshop
  • East Coast Research Camp
  • Other research related courses




Average Days

Start-Up timelines: <75 days
Quality: 94.8% (IQVIA Spotfire 19thOct 2018)
SIV to FPFV: <60 Days
Contract Executed timelines: 30 days


Read more contents from CRM Bulletin Issue 16. Download here!

Standard Operating Procedures (SOP)

  • Availability of CRM SOPs at site enable site to use it as reference/guide for the conduct of clinical trial.
  • Each CRM SCs are certified, and they can train other hospital site staff on the proper conduct of clinical trial.


IQVIA Prime Site

  • Hospital Raja Perempuan Zainab II was selected as one of the 11 Prime Site in Malaysia in 2013.
  • This partnership enables to benchmark Malaysia with other global countries for these contributing factors; increase number of clinical trial, improve start up timeline, High quality and meet/exceed patient recruitment targets.


PAREXEL Preferred Site

  • Officially selected as PAREXEL Preferred Site on 21stNov 2018.
  • Objective: to outline the preferred site strategy, better understand site’s areas of therapeutic interest, capabilities, capacity and infrastructure and explore whether there are areas of mutual interest.
  • Ultimately, if both parties felt there was a desire for, and benefit in, a more strategic collaboration, PAREXEL would work with site’s leadership team to increase the flow of clinical trial opportunities to site, identity a relationship manager within PAREXEL to oversee the collaboration and agree how best to optimise communication and processes between the two parties.

HRPZII awarded for Highest Number of Newly Approved Endocrinology Clinical Trials in Year 2016.


CRM has successfully achieved the accreditation for ISO 9001: 2015.


Hospital Sultanah Bahiyah

Hospital Sultanah Bahiyah (HSB) officially operated at its new building complex on 29 July 2007 after a complete transfer and replacing Hospital Alor Setar. Located 6 km from the centre of Alor Setar City, and within the sight of the PLUS North-South Highway, its location makes Hospital Sultanah Bahiyah easily accessible to the public. Surrounded by a vast area of paddy fields, this building complex incorporates 4 main buildings, namely the Medical Support Block, Ward Block, Main Block and Non-Medical Support Block. Read more

Clinical Research Centre (CRC) Hospital Sultan Ismail, Johor Bahru

Hospital Sultan Ismail Johor Bahru (HSIJB) began fully operational in May 2006 and was the second hospital in Malaysia that has started using the electronic system Total Hospital Information System (THIS). It currently has 18 specialists services with 21 subspecialties. HSIJB is a tertiary specialist hospital that is the main oncology centre in the southern region of Malaysia. Besides having a paediatric palliative care centre, it also has its own Clinical Research Centre (CRC) that supports both Industry Sponsored Research (ISR) as well as Investigator Initiated Research (IIR).

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UKMMC Cell Therapy Centre

Cell Therapy Center is one of the Center of Excellence in UKM Medical Centre (UKMMC) which provides cell-based therapy including hematopoietic stem cells, lymphocytes, dendritic cells, mesenchymal stem cells and mononuclear cells to patients with blood cancers, bone marrow diseases and degenerative diseases. The Cell Therapy Centre has the aspiration to be among the world leaders in research and development (R&D) of cancer immunotherapy and regenerative medicine.

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Clinical Research Centre Hospital Raja Permaisuri Bainun

Hospital Raja Permaisuri Bainun (HRPB) is currently the third largest Ministry of Health Hospital after Hospital Kuala Lumpur and Hospital Pulau Pinang. It is the main regional referral (tertiary) hospital for the state of Perak with major subspecialties servicing 14 other hospitals and 52 heath clinics. HRPB is also an active training centre for undergraduate, postgraduate, basic nursing and post basic nursing programs.

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Clinical Research Centre, Sarawak General Hospital

The new facility of Clinical Research Center Sarawak General Hospital (CRC SGH) was approved as an extension of the existing SGH in Kuching. The laying of the foundation stone commenced on 27 September 2007 by the Director General at that time, YBhg Tan Sri Dr Ismail Merican. The construction of the facility started on 15 January 2011 and completed on 10 July 2015. The new facility was handed over to end-user by the Secretary General of the Ministry of Health, YBhg. Datuk Dr. Chen Chaw Min on 19 July 2016.

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Clinical Research Ward, Hospital Ampang

Clinical Research Ward (CRW), Hospital Ampang was established in 2010 as a collaborative unit between a global contract research organization, named Veeda Clinical Research and the National Clinical Research Centre (NCRC), Ministry of Health. To embrace the collaboration, the facility was initially named as CRC-Veeda-Malaysia (CVM). The primary objective of the collaboration was to spearhead the development of early phase clinical research in Malaysia and to prepare a local team for conducting early phase clinical studies. More importantly, the collaboration provides a gateway to bring forward our local drug development from non-human phase to early phase clinical research. 

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Hospital Kuala Lumpur

Hospital Kuala Lumpur (HKL) is the largest hospital under the Ministry of Health Malaysia and is also one of the largest in Asia. It is a government tertiary referral hospital, located on 150 acres of prime land in the heart of Kuala Lumpur. HKL strives to be an institution of excellence in health care education and research, driven by a dedicated team providing professional client-centered service. The hospital provides secondary and tertiary care to the community. It is also a training centre for house officers, paramedics, radiographers, physiotherapists, occupational therapists and other health care workers as well as postgraduate trainees and subspecialty trainees.

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