Clinical Research Centre (CRC) Hospital Sultan Ismail, Johor Bahru

Hospital Sultan Ismail Johor Bahru (HSIJB) began fully operational in May 2006 and was the second hospital in Malaysia that has started using the electronic system Total Hospital Information System (THIS). It currently has 18 specialists services with 21 subspecialties. HSIJB is a tertiary specialist hospital that is the main oncology centre in the southern region of Malaysia. Besides having a paediatric palliative care centre, it also has its own Clinical Research Centre (CRC) that supports both Industry Sponsored Research (ISR) as well as Investigator Initiated Research (IIR). Read more

UKMMC Cell Therapy Centre

Cell Therapy Center is one of the Center of Excellence in UKM Medical Centre (UKMMC) which provides cell-based therapy including hematopoietic stem cells, lymphocytes, dendritic cells, mesenchymal stem cells and mononuclear cells to patients with blood cancers, bone marrow diseases and degenerative diseases. The Cell Therapy Centre has the aspiration to be among the world leaders in research and development (R&D) of cancer immunotherapy and regenerative medicine. Read more

Clinical Research Centre Hospital Raja Permaisuri Bainun

Hospital Raja Permaisuri Bainun (HRPB) is currently the third largest Ministry of Health Hospital after Hospital Kuala Lumpur and Hospital Pulau Pinang. It is the main regional referral (tertiary) hospital for the state of Perak with major subspecialties servicing 14 other hospitals and 52 heath clinics. HRPB is also an active training centre for undergraduate, postgraduate, basic nursing and post basic nursing programs.

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Clinical Research Centre, Sarawak General Hospital

The new facility of Clinical Research Center Sarawak General Hospital (CRC SGH) was approved as an extension of the existing SGH in Kuching. The laying of the foundation stone commenced on 27 September 2007 by the Director General at that time, YBhg Tan Sri Dr Ismail Merican. The construction of the facility started on 15 January 2011 and completed on 10 July 2015. The new facility was handed over to end-user by the Secretary General of the Ministry of Health, YBhg. Datuk Dr. Chen Chaw Min on 19 July 2016. Read more

Clinical Research Ward, Hospital Ampang

Clinical Research Ward (CRW), Hospital Ampang was established in 2010 as a collaborative unit between a global contract research organization, named Veeda Clinical Research and the National Clinical Research Centre (NCRC), Ministry of Health. To embrace the collaboration, the facility was initially named as CRC-Veeda-Malaysia (CVM). The primary objective of the collaboration was to spearhead the development of early phase clinical research in Malaysia and to prepare a local team for conducting early phase clinical studies. More importantly, the collaboration provides a gateway to bring forward our local drug development from non-human phase to early phase clinical research.  Read more

Hospital Kuala Lumpur

Hospital Kuala Lumpur (HKL) is the largest hospital under the Ministry of Health Malaysia and is also one of the largest in Asia. It is a government tertiary referral hospital, located on 150 acres of prime land in the heart of Kuala Lumpur. HKL strives to be an institution of excellence in health care education and research, driven by a dedicated team providing professional client-centered service. The hospital provides secondary and tertiary care to the community. It is also a training centre for house officers, paramedics, radiographers, physiotherapists, occupational therapists and other health care workers as well as postgraduate trainees and subspecialty trainees.


Provide quality healthcare that:

  • Is responsive to public, clients and employees needs;
  • Is delivered by a team of skilled, innovative, committed and compassionate personnel;
  • Involves partnership with individuals and the community for promotion of health;
  • Will undertake education and continuous professional development for all levels of staff; and
  • Conduct clinical research


  • To provide quality patient oriented service based on humanistic values emphasing customer satisfaction and encompassing promotive, preventive, curative and rehabilitative aspects;
  • To provide health education service to its clientele and provide post basic and continuing medical education to its staff to promote professionalism;
  • To instil excellent work culture and to create a conducive environment to deliver quality services;
  • To make HKL a centre of excellence and national referral centre,
  • To establish HKL as a clinical research centre.



Hospital Kuala Lumpur was selected to be included in the initial wave of Prime Sites, a collaboration between the Government of Malaysia (represented by the Ministry of Health) and Clinical Research Malaysia (CRM) with Quintiles.

Prime site is defined as a site targeted for intensified infrastructure and human resources development for improved participation of investigators in conducting clinical trials. The vision is to establish Prime Sites locally for clinical research, conducting benchmark trials with global impact.

The Prime Sites will develop long term strategic relationship with Quintiles to increase the number of industry sponsored research, improve start-up time and to meet or exceed patient recruitment targets.

There are currently 11 Prime Sites in Malaysia and this include:

  • Hospital Umum Sarawak
  • Hospital Sibu
  • Hospital Queen Elizabeth II
  • Hospital Raja Permaisuri Bainun
  • Hospital Sultanah Bahiyah
  • Hospital Raja Perempuan Zainab II
  • Hospital Tengku Ampuan Rahimah
  • Hospital Selayang
  • Hospital Kuala Lumpur
  • Hospital Pulau Pinang
  • Hospital Seberang Jaya




It was developed as a district hospital comprising of 3 wards i.e., the Tai Wah Ward, the Choudhry Ward and the Malay Ward.

Upgraded to 25 wards

Development of HKL from Phase I to Phase IV. The development of the various phases were as follows:

  • Phase I (1962 – 1968) Maternity Hospital, North Ward Block, Radiotherapy Department and Hostels for staff were built.
  • Phase II (1968 – 1972) South Ward Block, Neurology Institute, Surgical Block, Radiology Block, National Blood Transfusion Centre and more hostels were added.
  • Phase III (1972 – 1973) Specialist clinics, Outpatient Department and Doctor’s hostel were constructed. Phase IV-A (1973 – 1974) Trainee Nurses hostel and Clubhouse added.
  • Phase IV-B (1975): Orthopaedic Institute, Urology Institute, Artificial Limb Centre and Radiology Block built.

HKL started functioning as a teaching hospital for UKM medical students.

1989 – 1992
Paediatric Institute was constructed.

1994 – 1997 (Phase II)
Upgrading of the Institute of Radiotherapy, Oncology and Nuclear Medicine.

Specialist Complex & Ambulatory Care Centre (SCACC) was constructed.

Multi-storey Car Park opened to the public on 15 February 2015.

Current ongoing construction of Maternal & Child Hospital.





CRC HKL aims to capture investigator initiated research (IIR) conducted within HKL to observe the departmental performance. In 2015, a total of 217 IIRs were registered with CRC HKL. It has been encouraging to note that IIR spans across the 33 clinical departments in the hospital, with increasing activity among certain departments.

CRC HKL was established in November 2012. It is located at Level 7, Specialist Complex & Ambulatory Care (SCACC) Building, HKL where it actively assists investigators in various clinical research areas including Investigator Initiated Research (IIR) & Industry Sponsored Research (ISR). Since then, it expanded very well by leaps and bounds. The establishment of CRC HKL is essential to the growth of the research spirit among healthcare providers in HKL.

Currently, Dr. Hajjah Salina Abd Aziz spearheads the unit consisting of 8 dedicated medical officers and 5 allied health staffs. The symbiotic relationship with Clinical Research Malaysia (CRM) enables both sides to achieve our common goal. As of 2016, 11 CRM study coordinators have been placed in HKL to work hand in hand with CRC HKL and various investigators within the hospital.

CRC HKL aims to make HKL a main clinical research hub in Malaysia. Its’ mission is to improve the quality of health of patients through the application of high quality research studies.

Together, the team at CRC HKL is very committed to promote positive research attitudes and also in creating awareness amongst healthcare providers. The outreach is not only to doctors, but to all health care providers. Excellent programs have been implemented and are currently running to deliver that message to everyone especially to HKL staff. We hope to place Hospital Kuala Lumpur on the world map as a renowned hub of clinical research.



HRRC was established in May 2014. It began as one of the implementation of a new framework for research approval in Ministry of Health (MOH) through a pilot study that involved 3 other public hospitals. Recruitment of the HRRC members was done from various departments in HKL; consisting of Consultants, Specialists, Surgeons and Allied Health Officers. It started off with only 15 members and has since expanded to 38 members. The meeting is held every week and reviews an average of 4 proposals each week.


Read more contents from CRM Bulletin Issue 8. Download here!